Prostaglandin E2 modulation of vascular endothelial growth factor production in murine macrophages

M Mukutmoni, NE Hubbard, KL Erickson - … , Leukotrienes and Essential …, 2001 - Elsevier
We have previously shown that dietary (n-3) fatty acids decrease mammary tumor
vascularization and PGE2 production. One possible mechanism may be the modulation of
vascular endothelial growth factor (VEGF) production by PGE2. Macrophages are major
producers of VEGF, and thus we assessed the role of PGE2 in vitro and in vivo on their
VEGF production. When added to macrophages, pharmacological (10− 7 M) but not
physiological (10− 9 to 10− 11 M) concentrations of PGE2 increased VEGF mRNA and …