Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection
M Shahbazi, AA Fryer, V Pravica… - Journal of the …, 2002 - journals.lww.com
Acute rejection is a major cause of reduced survival of renal allografts. Vascular endothelial
growth factor (VEGF) is a mitogen for endothelial cells and is expressed widely by renal
tissue and T cells. VEGF influences adhesion and migration of leukocytes across the
endothelium. This study investigates whether genetically determined variation in VEGF
expression influences the development of renal allograft rejection. VEGF promoter
polymorphisms were examined by using sequence-specific primer–PCR in 173 renal …
growth factor (VEGF) is a mitogen for endothelial cells and is expressed widely by renal
tissue and T cells. VEGF influences adhesion and migration of leukocytes across the
endothelium. This study investigates whether genetically determined variation in VEGF
expression influences the development of renal allograft rejection. VEGF promoter
polymorphisms were examined by using sequence-specific primer–PCR in 173 renal …