The role of the podocyte in glomerulosclerosis
W Kriz, KV Lemley - Current opinion in nephrology and …, 1999 - journals.lww.com
W Kriz, KV Lemley
Current opinion in nephrology and hypertension, 1999•journals.lww.comFocal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive
renal disease. The 'classic'lesion, based on the adhesion of the capillary tuft to Bowman's
capsule, results from the loss of podocytes from the capillary basement membrane. The
recently described 'collapsing'variant, in contrast, has an apparent excess of extracapillary
cells, which may represent dedifferentiated,'dysregulated'podocytes.
renal disease. The 'classic'lesion, based on the adhesion of the capillary tuft to Bowman's
capsule, results from the loss of podocytes from the capillary basement membrane. The
recently described 'collapsing'variant, in contrast, has an apparent excess of extracapillary
cells, which may represent dedifferentiated,'dysregulated'podocytes.
Abstract
Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The ‘classic’lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane. The recently described ‘collapsing’variant, in contrast, has an apparent excess of extracapillary cells, which may represent dedifferentiated,‘dysregulated’podocytes.
Lippincott Williams & Wilkins