Ca2+ transport across the mitochondrial inner membrane is facilitated by transporters
having four distinct sets of characteristics as well as through the Ca2+-induced
mitochondrial permeability transition pore (PTP). There are two modes of inward transport,
referred to as the Ca2+ uniporter and the rapid mode or RaM. There are also two distinct
mechanisms mediating outward transport, which are not associated with the PTP, referred to
as the Na+-dependent and the Na+-independent Ca2+ efflux mechanisms. Several …