Cytokine/chemokine cascades in immunity to tuberculosis
IM Orme, AM Cooper - Immunology today, 1999 - cell.com
IM Orme, AM Cooper
Immunology today, 1999•cell.comThe relationship between acquired specific resistance and delayed-type hypersensitivity
(DTH) in immunity to tuberculosis has long been a topic of debate. Here, Ian Orme and
Andrea Cooper propose that the events are separate mechanisms; protection is cytokine
driven and initially controls the infection, whereas DTH is primarily chemokine driven and
functions to wall off the infection and prevent further dissemination.
(DTH) in immunity to tuberculosis has long been a topic of debate. Here, Ian Orme and
Andrea Cooper propose that the events are separate mechanisms; protection is cytokine
driven and initially controls the infection, whereas DTH is primarily chemokine driven and
functions to wall off the infection and prevent further dissemination.
Abstract
The relationship between acquired specific resistance and delayed-type hypersensitivity (DTH) in immunity to tuberculosis has long been a topic of debate. Here, Ian Orme and Andrea Cooper propose that the events are separate mechanisms; protection is cytokine driven and initially controls the infection, whereas DTH is primarily chemokine driven and functions to wall off the infection and prevent further dissemination.
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