Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based …
MR Pelot, DA Pearson, K Swenson, G Zhao… - Biology of Blood and …, 1999 - astctjournal.org
Mixed hematopoietic chimerism can be induced in mice receiving allogeneic bone marrow
transplantation (BMT) after nonmyeloablative host conditioning with depletion T cells with of
anti-T cell monoclonal antibodies (mAbs), low-dose (3 Gy) total-body irradiation (TBI), and
local thymic irradiation (7 Gy). These mice are specifically tolerant to donor and host
antigens. When nontolerant donor T cells are given to chimeras several months after BMT,
full donor-type chimerism develops, but graft-vs.-host disease (GVHD) does not occur. The …
transplantation (BMT) after nonmyeloablative host conditioning with depletion T cells with of
anti-T cell monoclonal antibodies (mAbs), low-dose (3 Gy) total-body irradiation (TBI), and
local thymic irradiation (7 Gy). These mice are specifically tolerant to donor and host
antigens. When nontolerant donor T cells are given to chimeras several months after BMT,
full donor-type chimerism develops, but graft-vs.-host disease (GVHD) does not occur. The …