Transplants across human leukocyte antigen barriers
MF Martelli, F Aversa, E Bachar-Lustig, A Velardi… - Seminars in …, 2002 - Elsevier
Clinical experience with full haplotype-mismatched stem cell transplants has a 20-year
history. Early results in leukemia patients were disappointing because of a high incidence of
severe graft-versus-host disease (GvHD) in T-replete transplants or high rejection rates in T-
cell–depleted transplants. The breakthrough came with introduction of a megadose T-cell–
depleted progenitor cell transplant following a high-intensity conditioning regimen and the
realization that donor natural killer (NK) cell alloreactivity also plays a role in facilitating …
history. Early results in leukemia patients were disappointing because of a high incidence of
severe graft-versus-host disease (GvHD) in T-replete transplants or high rejection rates in T-
cell–depleted transplants. The breakthrough came with introduction of a megadose T-cell–
depleted progenitor cell transplant following a high-intensity conditioning regimen and the
realization that donor natural killer (NK) cell alloreactivity also plays a role in facilitating …