[HTML][HTML] Gi protein-mediated functional compartmentalization of cardiac β2-adrenergic signaling
M Kuschel, YY Zhou, H Cheng, SJ Zhang… - Journal of Biological …, 1999 - ASBMB
In contrast to β 1-adrenoreceptor (β 1-AR) signaling, β 2-AR stimulation in cardiomyocytes
augmentsl-type Ca 2+ current in a cAMP-dependent protein kinase (PKA)-dependent
manner but fails to phosphorylate phospholamban, indicating that the β 2-AR-induced
cAMP/PKA signaling is highly localized. Here we show that inhibition of G i proteins with
pertussis toxin (PTX) permits a full phospholamban phosphorylation and a de novo relaxant
effect following β 2-AR stimulation, converting the localized β 2-AR signaling to a global …
augmentsl-type Ca 2+ current in a cAMP-dependent protein kinase (PKA)-dependent
manner but fails to phosphorylate phospholamban, indicating that the β 2-AR-induced
cAMP/PKA signaling is highly localized. Here we show that inhibition of G i proteins with
pertussis toxin (PTX) permits a full phospholamban phosphorylation and a de novo relaxant
effect following β 2-AR stimulation, converting the localized β 2-AR signaling to a global …