Renal cell-urinary crystal interactions
JC Lieske, FG Toback - Current opinion in nephrology and …, 2000 - journals.lww.com
JC Lieske, FG Toback
Current opinion in nephrology and hypertension, 2000•journals.lww.comCrystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical
surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically
with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate
directly on the plasma membrane. The internalization of adherent crystals, changes in gene
expression, and secretion of specific proteins ensue, and appear to be important processes
in crystal retention and kidney stone pathogenesis.
surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically
with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate
directly on the plasma membrane. The internalization of adherent crystals, changes in gene
expression, and secretion of specific proteins ensue, and appear to be important processes
in crystal retention and kidney stone pathogenesis.
Abstract
Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. The internalization of adherent crystals, changes in gene expression, and secretion of specific proteins ensue, and appear to be important processes in crystal retention and kidney stone pathogenesis.
Lippincott Williams & Wilkins