Unmasking a killer: DNA O6-methylguanine and the cytotoxicity of methylating agents
M Bignami, M O'Driscoll, G Aquilina, P Karran - Mutation Research/Reviews …, 2000 - Elsevier
Methylating agents are potent carcinogens that are mutagenic and cytotoxic towards
bacteria and mammalian cells. Their effects can be ascribed to an ability to modify DNA
covalently. Pioneering studies of the chemical reactivity of methylating agents towards DNA
components and their effectiveness as animal carcinogens identified O6-methylguanine
(O6meG) as a potentially important DNA lesion. Subsequent analysis of the effects of
methylating carcinogens in bacteria and cultured mammalian cells—including the discovery …
bacteria and mammalian cells. Their effects can be ascribed to an ability to modify DNA
covalently. Pioneering studies of the chemical reactivity of methylating agents towards DNA
components and their effectiveness as animal carcinogens identified O6-methylguanine
(O6meG) as a potentially important DNA lesion. Subsequent analysis of the effects of
methylating carcinogens in bacteria and cultured mammalian cells—including the discovery …