Nitric oxide is a key participant in many physiological pathways; however, its reactivity gives
it the potential to cause considerable damage to cells and tissues in its vicinity. Nitric oxide
can react with DNA via multiple pathways. Once produced, subsequent conversion of nitric
oxide to nitrous anhydride and/or peroxynitrite can lead to the nitrosative deamination of
DNA bases such as guanine and cytosine. Complex oxidation chemistry can also occur
causing DNA base and sugar oxidative modifications. This review describes the different …