Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions
TK Hazra, JW Hill, T Izumi, S Mitra - Progress in nucleic acid research and …, 2001 - Elsevier
Oxoguanine (8-oxoG) is a critical mutagenic lesion because of its propensity to mispair with
A during DNA replication. All organisms, from bacteria to mammals, express at least two
types of 8-oxoguanine-DNA glycosylase (OGG) for repair of 8-oxoG. The major enzyme
class (OGGI), first identified in Escherichia coli as Mutts (Fpg), and later in yeast and
humans, excises 8-oxoG when paired with C, T, and G but rarely with A. In contrast, a distinct
and less abundant OGG, OGG2, prefers 8-oxoG when paired with G and A as a substrate …
A during DNA replication. All organisms, from bacteria to mammals, express at least two
types of 8-oxoguanine-DNA glycosylase (OGG) for repair of 8-oxoG. The major enzyme
class (OGGI), first identified in Escherichia coli as Mutts (Fpg), and later in yeast and
humans, excises 8-oxoG when paired with C, T, and G but rarely with A. In contrast, a distinct
and less abundant OGG, OGG2, prefers 8-oxoG when paired with G and A as a substrate …