[HTML][HTML] Series Introduction: COX in a crystal ball: current status and future promise of prostaglandin research
GA FitzGerald, P Loll - The Journal of clinical investigation, 2001 - Am Soc Clin Investig
The Journal of clinical investigation, 2001•Am Soc Clin Investig
The COX-1 and COX-2 backbones, overlaid. COX-1 is shown in yellow, and COX-2 in red.
Note how the two structures are almost perfectly superimposable. The amphipathic helices
that form the site of monotopic membrane attachment are indicated. The peroxidase (POX)
active site lies on the opposite side of the molecule from the entrance to the COX active site
channel. The actual position of the COX active center is marked by the asterisk, found near
the center of the molecule.
Note how the two structures are almost perfectly superimposable. The amphipathic helices
that form the site of monotopic membrane attachment are indicated. The peroxidase (POX)
active site lies on the opposite side of the molecule from the entrance to the COX active site
channel. The actual position of the COX active center is marked by the asterisk, found near
the center of the molecule.
The COX-1 and COX-2 backbones, overlaid. COX-1 is shown in yellow, and COX-2 in red. Note how the two structures are almost perfectly superimposable. The amphipathic helices that form the site of monotopic membrane attachment are indicated. The peroxidase (POX) active site lies on the opposite side of the molecule from the entrance to the COX active site channel. The actual position of the COX active center is marked by the asterisk, found near the center of the molecule.
The Journal of Clinical Investigation