Deficiency of reduced nicotinamide-adenine dinucleotide oxidase in chronic granulomatous disease
RL Baehner, ML Karnovsky - Science, 1968 - science.org
RL Baehner, ML Karnovsky
Science, 1968•science.orgReduced nicotinamide-adenine dinucleotide oxidase of normal human polymorphonuclear
leukocytes has properties that would qualify it as the enzyme responsible for the respiratory
burst during phagocytosis. The enzyme was deficient in leukocytes of five patients with
chronic granulomatous disease. This lack of adequate reduced nicotinamide-adenine
dinucleotide oxidase could be the basis for the metabolic abnormalities characteristic of
these leukocytes and for their diminished bactericidal activity.
leukocytes has properties that would qualify it as the enzyme responsible for the respiratory
burst during phagocytosis. The enzyme was deficient in leukocytes of five patients with
chronic granulomatous disease. This lack of adequate reduced nicotinamide-adenine
dinucleotide oxidase could be the basis for the metabolic abnormalities characteristic of
these leukocytes and for their diminished bactericidal activity.
Reduced nicotinamide-adenine dinucleotide oxidase of normal human polymorphonuclear leukocytes has properties that would qualify it as the enzyme responsible for the respiratory burst during phagocytosis. The enzyme was deficient in leukocytes of five patients with chronic granulomatous disease. This lack of adequate reduced nicotinamide-adenine dinucleotide oxidase could be the basis for the metabolic abnormalities characteristic of these leukocytes and for their diminished bactericidal activity.
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