[HTML][HTML] Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation
I Strehlow, C Schindler - Journal of Biological Chemistry, 1998 - ASBMB
The first∼ 100 amino acids of the STAT (signal transducer and activator oftranscription)
family of transcription factors share a high degree of sequence similarity. To determine
whether they encode a functionally conserved domain, amino-terminal chimeric STATs were
created. These chimeric STATs share a number of properties with wild-type Stat1, including
a predominately cytoplasmic pattern of expression in unstimulated cells. Upon stimulation
with ligand, the chimeric STATs rapidly become tyrosine-phosphorylated, dimerize, and are …
family of transcription factors share a high degree of sequence similarity. To determine
whether they encode a functionally conserved domain, amino-terminal chimeric STATs were
created. These chimeric STATs share a number of properties with wild-type Stat1, including
a predominately cytoplasmic pattern of expression in unstimulated cells. Upon stimulation
with ligand, the chimeric STATs rapidly become tyrosine-phosphorylated, dimerize, and are …