[HTML][HTML] Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor
DX Fu, SM Sine - Journal of Biological Chemistry, 1996 - ASBMB
The acetylcholine receptor (AChR) at the motor synapse is a pentamer of homologous
subunits with the composition α 2 βγδ. Owing to the circular arrangement of subunits that
forms a central ion channel, each subunit interface contains contributions from opposite
faces of each subunit, designated+ and−. Common to all subunits of the AChR and
members of its superfamily is a disulfide loop formed between cysteines 128 and 142 of the
major extracellular domain. To gain insight into the structural contribution of the disulfide …
subunits with the composition α 2 βγδ. Owing to the circular arrangement of subunits that
forms a central ion channel, each subunit interface contains contributions from opposite
faces of each subunit, designated+ and−. Common to all subunits of the AChR and
members of its superfamily is a disulfide loop formed between cysteines 128 and 142 of the
major extracellular domain. To gain insight into the structural contribution of the disulfide …