[HTML][HTML] Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
Mitochondrial uncoupling proteins (UCPs) are transporters that are important for
thermogenesis. The net result of their activity is the exothermic movement of protons through
the inner mitochondrial membrane, uncoupled from ATP synthesis. We have cloned a third
member of the UCP family, UCP3. UCP3 is expressed at high levels in muscle and rodent
brown adipose tissue. Overexpression in yeast reduced the mitochondrial membrane
potential, showing that UCP3 is a functional uncoupling protein. UCP3 RNA levels are …
thermogenesis. The net result of their activity is the exothermic movement of protons through
the inner mitochondrial membrane, uncoupled from ATP synthesis. We have cloned a third
member of the UCP family, UCP3. UCP3 is expressed at high levels in muscle and rodent
brown adipose tissue. Overexpression in yeast reduced the mitochondrial membrane
potential, showing that UCP3 is a functional uncoupling protein. UCP3 RNA levels are …