Extracellular matrix remodeling in coxsackievirus B3 myocarditis
C Kishimoto, M Kitazawa, Y Hiraoka… - Clinical immunology and …, 1997 - Elsevier
The connective tissue abnormality in relation to T lymphocytes was investigated in murine
myocarditis. Inbred BALB/c-nu/+(euthymic and normal T cell function) and BALB/c-nu/nu
(athymic and T cell deficient) mice were inoculated with coxsackievirus B3 (CB3). Hearts
were stained with hematoxylin–eosin, Mallory-azan, and silver impregnation, for reticulin
fiber abnormalities, and T lymphocyte subsets. In BALB/c-nu/+ mice, active myocardial
necrosis appeared parallel with T lymphocyte infiltrates, that is, it was absent on day 0 …
myocarditis. Inbred BALB/c-nu/+(euthymic and normal T cell function) and BALB/c-nu/nu
(athymic and T cell deficient) mice were inoculated with coxsackievirus B3 (CB3). Hearts
were stained with hematoxylin–eosin, Mallory-azan, and silver impregnation, for reticulin
fiber abnormalities, and T lymphocyte subsets. In BALB/c-nu/+ mice, active myocardial
necrosis appeared parallel with T lymphocyte infiltrates, that is, it was absent on day 0 …