Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk
CH Jensen, M Meyer, HD Schroder, A Kliem… - …, 2001 - journals.lww.com
The gene DLK1 encodes a member of the epidermal growth factor (EGF) superfamily, delta-
like (dlk). When exposed in vivo to the action of an unknown protease, this type 1 membrane
protein generates a soluble peptide referred to as Fetal antigen 1 (FA1). By acting in
juxtacrine as well as paracrine/autocrine manners, both forms have been shown to be active
in the differentiation/proliferation process of various cell types. In adults, FA1/dlk has been
demonstrated mainly within (neuro) endocrine tissues. In this study we investigated the …
like (dlk). When exposed in vivo to the action of an unknown protease, this type 1 membrane
protein generates a soluble peptide referred to as Fetal antigen 1 (FA1). By acting in
juxtacrine as well as paracrine/autocrine manners, both forms have been shown to be active
in the differentiation/proliferation process of various cell types. In adults, FA1/dlk has been
demonstrated mainly within (neuro) endocrine tissues. In this study we investigated the …