[HTML][HTML] G protein selectivity is a determinant of RGS2 function

SP Heximer, SP Srinivasa, LS Bernstein… - Journal of Biological …, 1999 - ASBMB
RGS (regulator of Gprotein signaling) proteins are GTPase-activating proteins that attenuate
signaling by heterotrimeric G proteins. Whether the biological functions of RGS proteins are
governed by quantitative differences in GTPase-activating protein activity toward various
classes of Gα subunits and how G protein selectivity is achieved by differences in RGS
protein structure are largely unknown. Here we provide evidence indicating that the function
of RGS2 is determined in part by differences in potency toward G q versus G i family …