[HTML][HTML] Role of the postsynaptic α2-adrenergic receptor subtypes in catecholamine-induced vasoconstriction
I Duka, I Gavras, C Johns, DE Handy… - … : The Vascular System, 2000 - Elsevier
Catecholamines induce direct vasoconstriction mediated by postsynaptic α-adrenergic
receptors (α-ARs) of both the α1 and α2 type. To evaluate the contribution of each α2-AR
subtype (α2A, α2B, and α2C) to this function, we used groups of genetically engineered
mice deficient for the gene to each one of these subtypes and compared their blood
pressure (BP) responses to their wild-type counterparts. Blood pressure responses to a
bolus of norepinephrine (NE) were assessed before and after sequential blockade of α1 …
receptors (α-ARs) of both the α1 and α2 type. To evaluate the contribution of each α2-AR
subtype (α2A, α2B, and α2C) to this function, we used groups of genetically engineered
mice deficient for the gene to each one of these subtypes and compared their blood
pressure (BP) responses to their wild-type counterparts. Blood pressure responses to a
bolus of norepinephrine (NE) were assessed before and after sequential blockade of α1 …