How receptors talk to trimeric G proteins
HR Bourne - Current opinion in cell biology, 1997 - Elsevier
HR Bourne
Current opinion in cell biology, 1997•ElsevierStimulated by hormones and sensory stimuli, serpentine receptors promote the release of
GDP that is bound to the α subunit of trimeric G proteins and its replacement by GTP. Recent
investigations have begun to define the sizes, shapes, and relative orientations of receptors
and G proteins, the surfaces through which they interact with one another, and
conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-
nucleotide exchange.
GDP that is bound to the α subunit of trimeric G proteins and its replacement by GTP. Recent
investigations have begun to define the sizes, shapes, and relative orientations of receptors
and G proteins, the surfaces through which they interact with one another, and
conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-
nucleotide exchange.
Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the α subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, the surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.
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