[HTML][HTML] Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride …
M Merkel, J Heeren, W Dudeck, F Rinninger… - Journal of Biological …, 2002 - ASBMB
We have previously shown that transgenic expression of catalytically inactive lipoprotein
lipase (LPL) in muscle (Mck-N-LPL) enhances triglyceride hydrolysis as well as whole
particle lipoprotein and selective cholesterol ester uptake. In the current study, we have
examined whether these functions can be performed by inactive LPL alone or require the
presence of active LPL expressed in the same tissue. To study inactive LPL in the presence
of active LPL in the same tissue, the Mck-N-LPL transgene was bred onto the heterozygous …
lipase (LPL) in muscle (Mck-N-LPL) enhances triglyceride hydrolysis as well as whole
particle lipoprotein and selective cholesterol ester uptake. In the current study, we have
examined whether these functions can be performed by inactive LPL alone or require the
presence of active LPL expressed in the same tissue. To study inactive LPL in the presence
of active LPL in the same tissue, the Mck-N-LPL transgene was bred onto the heterozygous …