[HTML][HTML] Thermogenic responses in brown fat cells are fully UCP1-dependent: UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty acid-induced …
A Matthias, KBE Ohlson, JM Fredriksson… - Journal of Biological …, 2000 - ASBMB
To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the
thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was
investigated. Ucp1 (−/−) cells had a basal metabolic rate identical to wild-type; the
mitochondria within them were coupled to the same degree. The response to
norepinephrine in wild-type cells was robust (≈ 10-fold increase in thermogenesis); Ucp1
(−/−) cells only responded≈ 3% of this. Ucp1 (−/−) cells were as potent as wild-type in …
thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was
investigated. Ucp1 (−/−) cells had a basal metabolic rate identical to wild-type; the
mitochondria within them were coupled to the same degree. The response to
norepinephrine in wild-type cells was robust (≈ 10-fold increase in thermogenesis); Ucp1
(−/−) cells only responded≈ 3% of this. Ucp1 (−/−) cells were as potent as wild-type in …