[HTML][HTML] Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
Uncoupling protein-3 (UCP3) is a mitochondrial protein that can diminish the mitochondrial
membrane potential. Levels of muscle Ucp3 mRNA are increased by thyroid hormone and
fasting. Ucp3 has been proposed to influence metabolic efficiency and is a candidate
obesity gene. We have produced aUcp3 knockout mouse to test these hypotheses. TheUcp3
(−/−) mice had no detectable immunoreactive UCP3 by Western blotting. In mitochondria
from the knockout mice, proton leak was greatly reduced in muscle, minimally reduced in …
membrane potential. Levels of muscle Ucp3 mRNA are increased by thyroid hormone and
fasting. Ucp3 has been proposed to influence metabolic efficiency and is a candidate
obesity gene. We have produced aUcp3 knockout mouse to test these hypotheses. TheUcp3
(−/−) mice had no detectable immunoreactive UCP3 by Western blotting. In mitochondria
from the knockout mice, proton leak was greatly reduced in muscle, minimally reduced in …