[HTML][HTML] Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase

LJ Brown, RA Koza, C Everett, ML Reitman… - Journal of Biological …, 2002 - ASBMB
The mitochondrial glycerol phosphate dehydrogenase (mGPD) is important for metabolism
of glycerol phosphate for gluconeogenesis or energy production and has been implicated in
thermogenesis induced by cold and thyroid hormone treatment. mGPD in combination with
the cytosolic glycerol phosphate dehydrogenase (cGPD) is proposed to form the glycerol
phosphate shuttle, catalyzing the interconversion of dihydroxyacetone phosphate and
glycerol phosphate with net oxidation of cytosolic NADH. We made a targeted deletion …