[HTML][HTML] FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance

A Cederberg, LM Grřnning, B Ahrén, K Taskén… - Cell, 2001 - cell.com
A Cederberg, LM Grřnning, B Ahrén, K Taskén, P Carlsson, S Enerbäck
Cell, 2001cell.com
Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2 diabetes
mellitus. We have identified the human winged helix/forkhead transcription factor gene
FOXC2 as a key regulator of adipocyte metabolism. Increased FOXC2 expression, in
adipocytes, has a pleiotropic effect on gene expression, which leads to a lean and insulin
sensitive phenotype. FOXC2 affects adipocyte metabolism by increasing the sensitivity of the
β-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of …
Abstract
Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2 diabetes mellitus. We have identified the human winged helix/forkhead transcription factor gene FOXC2 as a key regulator of adipocyte metabolism. Increased FOXC2 expression, in adipocytes, has a pleiotropic effect on gene expression, which leads to a lean and insulin sensitive phenotype. FOXC2 affects adipocyte metabolism by increasing the sensitivity of the β-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition. Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity, including hypertriglyceridemia and diet-induced insulin resistance—a likely consequence hereof would be protection against type 2 diabetes.
cell.com