Double-strand breaks and tumorigenesis
Trends in cell biology, 2001•cell.com
The establishment of connections between biochemical defects and clinical disease is a
major goal of modern molecular genetics. In this review, we examine the current literature
that relates defects in the two major DNA double-strand-break repair pathways–homologous
recombination and nonhomologous end-joining–with the development of human tumors.
Although definitive proof has yet to be obtained, the current literature is highly suggestive of
such a link.
major goal of modern molecular genetics. In this review, we examine the current literature
that relates defects in the two major DNA double-strand-break repair pathways–homologous
recombination and nonhomologous end-joining–with the development of human tumors.
Although definitive proof has yet to be obtained, the current literature is highly suggestive of
such a link.
Abstract
The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways – homologous recombination and nonhomologous end-joining – with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link.
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