[HTML][HTML] Effect of loss of P2Y2 receptor gene expression on nucleotide regulation of murine epithelial Cl− transport
VL Cressman, E Lazarowski, L Homolya… - Journal of Biological …, 1999 - ASBMB
Extracellular nucleotides are believed to be important regulators of ion transport in epithelial
tissues as a result of their ability to activate cell surface receptors. Although numerous
receptors that bind nucleotides have been identified, the complexity of this receptor family,
combined with the lack of pharmacological agents specific for these receptors, has made the
assignment of particular receptors and ligands to physiological responses difficult. Because
ATP and UTP appear equipotent and equieffective in regulating ion transport in many …
tissues as a result of their ability to activate cell surface receptors. Although numerous
receptors that bind nucleotides have been identified, the complexity of this receptor family,
combined with the lack of pharmacological agents specific for these receptors, has made the
assignment of particular receptors and ligands to physiological responses difficult. Because
ATP and UTP appear equipotent and equieffective in regulating ion transport in many …