[HTML][HTML] Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A
Y Jia, CJ Mathews, JW Hanrahan - Journal of Biological Chemistry, 1997 - ASBMB
Protein kinase A (PKA) stimulates Cl secretion by activating the cystic fibrosis
transmembrane conductance regulator (CFTR), a tightly regulated Cl− channel in the apical
membrane of many secretory epithelia. The CFTR channel is also modulated by protein
kinase C (PKC), but the regulatory mechanisms are poorly understood. Here we present
evidence that PKA-mediated phosphorylation alone is not a sufficient stimulus to open the
CFTR chloride channel in the presence of MgATP; constitutive PKC phosphorylation is …
transmembrane conductance regulator (CFTR), a tightly regulated Cl− channel in the apical
membrane of many secretory epithelia. The CFTR channel is also modulated by protein
kinase C (PKC), but the regulatory mechanisms are poorly understood. Here we present
evidence that PKA-mediated phosphorylation alone is not a sufficient stimulus to open the
CFTR chloride channel in the presence of MgATP; constitutive PKC phosphorylation is …