[HTML][HTML] Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice
H Yagyu, S Ishibashi, Z Chen, J Osuga, M Okazaki… - Journal of lipid …, 1999 - ASBMB
Lipoprotein lipase (LPL) is known to play a crucial role in lipoprotein metabolism by
hydrolyzing triglycerides; however its role in atherogenesis has yet to be determined. We
have previously shown that low density lipoprotein receptor knockout mice overexpressing
LPL are resistant to diet-induced atherosclerosis due to the suppression of remnant
lipoproteins. Plasma lipoproteins and atherosclerosis of apolipoprotein (apo) E knockout
mice which overexpress the human LPL transgene (LPL/APOEKO) were compared with …
hydrolyzing triglycerides; however its role in atherogenesis has yet to be determined. We
have previously shown that low density lipoprotein receptor knockout mice overexpressing
LPL are resistant to diet-induced atherosclerosis due to the suppression of remnant
lipoproteins. Plasma lipoproteins and atherosclerosis of apolipoprotein (apo) E knockout
mice which overexpress the human LPL transgene (LPL/APOEKO) were compared with …