Fyn tyrosine kinase participates in the compact myelin sheath formation in the central nervous system
C Seiwa, I Sugiyama, T Yagi, T Iguchi, H Asou - Neuroscience research, 2000 - Elsevier
The cellular mechanisms for spiral wrapping and compaction of myelin sheaths by
oligodendrocytes are not known yet. In this study, we examined the role of fyn tyrosine
kinase, which could be responsible for molecular events during the stage of myelination in
the CNS. Western blot and immunohistochemical analyses revealed that fyn-deficient mice
have significantly lower levels of myelin basic protein (MBP), which is required for
intracellular membrane adhesion parts so-called major dense line (MDL) and thought to be …
oligodendrocytes are not known yet. In this study, we examined the role of fyn tyrosine
kinase, which could be responsible for molecular events during the stage of myelination in
the CNS. Western blot and immunohistochemical analyses revealed that fyn-deficient mice
have significantly lower levels of myelin basic protein (MBP), which is required for
intracellular membrane adhesion parts so-called major dense line (MDL) and thought to be …