Oxidative damage to skeletal muscle DNA from patients with mitochondrial encephalomyopathies
T Mitsui, H Kawai, M Nagasawa, M Kunishige… - Journal of the …, 1996 - Elsevier
To estimate the oxidative damage to skeletal muscle DNA in mitochondrial
encephalomyopathies, we studied the amount of 8-hydroxy-deoxyguanosine (8-OH-dG) and
the localization of superoxide dismutase (SOD) in the skeletal muscles of patients with
progressive external ophthalmoplegia (PEO) or Kearns-Sayre syndrome (KSS). The molar
ratio of 8-OH-dG/deoxyguanosine in skeletal muscle from PEO or KSS patients was
significantly higher than the control value. The ratio from patients with polymyositis or …
encephalomyopathies, we studied the amount of 8-hydroxy-deoxyguanosine (8-OH-dG) and
the localization of superoxide dismutase (SOD) in the skeletal muscles of patients with
progressive external ophthalmoplegia (PEO) or Kearns-Sayre syndrome (KSS). The molar
ratio of 8-OH-dG/deoxyguanosine in skeletal muscle from PEO or KSS patients was
significantly higher than the control value. The ratio from patients with polymyositis or …