Sequence and organization of the human mitochondrial genome
S Anderson, AT Bankier, BG Barrell, MHL de Bruijn… - Nature, 1981 - nature.com
S Anderson, AT Bankier, BG Barrell, MHL de Bruijn, AR Coulson, J Drouin, IC Eperon…
Nature, 1981•nature.comThe complete sequence of the 16,569-base pair human mitochondrial genome is presented.
The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III,
ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been
located. The sequence shows extreme economy in that the genes have none or only a few
noncoding bases between them, and in many cases the termination codons are not coded in
the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III,
ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been
located. The sequence shows extreme economy in that the genes have none or only a few
noncoding bases between them, and in many cases the termination codons are not coded in
the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
Abstract
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
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