[HTML][HTML] Abnormalities of Striatal Projection Neurons and N-Methyl-D-Aspartate Receptors in Presymptomatic Huntington's Disease

RL Albin, AB Young, JB Penney… - … England Journal of …, 1990 - Mass Medical Soc
RL Albin, AB Young, JB Penney, B Handelin, R Balfour, KD Anderson, DS Markel
New England Journal of Medicine, 1990Mass Medical Soc
HUNTINGTON'S disease is an autosomal dominant disease characterized by slowly
progressive personality changes, dementia, and movement disorders. 1, 2 The average age
at onset is 30 to 40 years, and the disease lasts for an average of 15 to 20 years. Analysis
with restriction-fragmentlength polymorphisms (RFLPs) has localized the Huntington's
disease gene close to the telomere of the short arm of chromosome 4.1 2 3 Prominent
striatal atrophy with loss of striatal neurons and relative sparing of fibers of passage and …
HUNTINGTON'S disease is an autosomal dominant disease characterized by slowly progressive personality changes, dementia, and movement disorders.1 , 2 The average age at onset is 30 to 40 years, and the disease lasts for an average of 15 to 20 years. Analysis with restriction-fragmentlength polymorphisms (RFLPs) has localized the Huntington's disease gene close to the telomere of the short arm of chromosome 4.1 2 3 Prominent striatal atrophy with loss of striatal neurons and relative sparing of fibers of passage and afferent axons is the pathological hallmark of Huntington's disease.4 Recent studies have demonstrated a distinct pattern of vulnerability of striatal neurons in Huntington's . . .
The New England Journal Of Medicine