[HTML][HTML] A Sp1 binding site of the tumor necrosis factor α promoter functions as a nitric oxide response element
S Wang, W Wang, RA Wesley, RL Danner - Journal of Biological Chemistry, 1999 - ASBMB
Regulation of gene transcription is an incompletely understood function of nitric oxide (NO).
Human leukocytes produce increased amounts of tumor necrosis factor α (TNF-α) in
response to NO. This effect is associated with decreases in intracellular cAMP, suggesting
that NO might regulate gene transcription through promoter sequences sensitive to cAMP
such as cAMP response elements (CRE) and Sp1 binding sites. Here we report that a Sp1
binding site in the TNF-α promoter conveys NO responsiveness. Human U937 cells were …
Human leukocytes produce increased amounts of tumor necrosis factor α (TNF-α) in
response to NO. This effect is associated with decreases in intracellular cAMP, suggesting
that NO might regulate gene transcription through promoter sequences sensitive to cAMP
such as cAMP response elements (CRE) and Sp1 binding sites. Here we report that a Sp1
binding site in the TNF-α promoter conveys NO responsiveness. Human U937 cells were …