[HTML][HTML] Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition

BS Kristal, AM Brown - Journal of Biological Chemistry, 1999 - ASBMB
Early events in apoptotic cascades initiated by ceramides or by activation of the surface
receptor CD95 (Fas/APO-1) include the formation of ganglioside GD3. GD3 appears to be
both necessary and sufficient to propagate this lipid-mediated apoptotic pathway. Later
events common to many apoptotic pathways include induction of the mitochondrial
permeability transition (PT) and cytochrome c release, which in turn triggers downstream
caspases and cell death. The links between GD3 formation and downstream stages of …