[HTML][HTML] Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene
SL Schissel, EH Schuchman, KJ Williams… - Journal of Biological …, 1996 - ASBMB
Mammalian sphingomyelinases have been implicated in many important physiological and
pathophysiological processes. Although several mammalian sphingomyelinases have been
identified and studied, one of these, an acidic Zn 2+-stimulated sphingomyelinase (Zn-
SMase) originally found in fetal bovine serum, has received little attention since its first and
only report 7 years ago. We now show that Zn-SMase activity is secreted by human and
murine macrophages, human skin fibroblasts, microglial cells, and several other cells in …
pathophysiological processes. Although several mammalian sphingomyelinases have been
identified and studied, one of these, an acidic Zn 2+-stimulated sphingomyelinase (Zn-
SMase) originally found in fetal bovine serum, has received little attention since its first and
only report 7 years ago. We now show that Zn-SMase activity is secreted by human and
murine macrophages, human skin fibroblasts, microglial cells, and several other cells in …