[HTML][HTML] The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow
W Shen, LJ Bendall, DJ Gottlieb, KF Bradstock - Experimental hematology, 2001 - Elsevier
OBJECTIVES: It has been demonstrated that acute lymphoblastic leukemia (ALL) blasts
migrate into layers of bone marrow fibroblasts (BMF) in vitro using the β1 integrins VLA-4
and VLA-5, and that the chemokine SDF-1 and its receptor CXCR4 influences ALL
migration. We investigated whether this effect was due to SDF-1–mediated induction of
adhesion through β1 integrins. METHODS: Adhesion of pre-B ALL cells or the cell line
NALM6 to extracellular matrix proteins was examined using short-term in vitro binding …
migrate into layers of bone marrow fibroblasts (BMF) in vitro using the β1 integrins VLA-4
and VLA-5, and that the chemokine SDF-1 and its receptor CXCR4 influences ALL
migration. We investigated whether this effect was due to SDF-1–mediated induction of
adhesion through β1 integrins. METHODS: Adhesion of pre-B ALL cells or the cell line
NALM6 to extracellular matrix proteins was examined using short-term in vitro binding …