[HTML][HTML] Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice
S Kudoh, I Komuro, Y Hiroi, Y Zou, K Harada… - Journal of Biological …, 1998 - ASBMB
Many lines of evidence have suggested that angiotensin II (AngII) plays an important role in
the development of cardiac hypertrophy through AngII type 1 receptor (AT1). To determine
whether AngII is indispensable for the development of mechanical stress-induced cardiac
hypertrophy, we examined the activity of mitogen-activated protein kinase (MAPK) family
and the expression of the c-fos gene as hypertrophic responses after stretching cultured
cardiac myocytes of AT1a knockout (KO) mice. When cardiac myocytes were stretched by …
the development of cardiac hypertrophy through AngII type 1 receptor (AT1). To determine
whether AngII is indispensable for the development of mechanical stress-induced cardiac
hypertrophy, we examined the activity of mitogen-activated protein kinase (MAPK) family
and the expression of the c-fos gene as hypertrophic responses after stretching cultured
cardiac myocytes of AT1a knockout (KO) mice. When cardiac myocytes were stretched by …