[HTML][HTML] The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation: a novel mechanism of toxicity
J Lotharius, KL O'Malley - Journal of Biological Chemistry, 2000 - ASBMB
Uptake of the Parkinsonism-inducing toxin, 1-methyl-4-phenylpyridinium (MPP+), into
dopaminergic terminals is thought to block Complex I activity leading to ATP loss and
overproduction of reactive oxygen species (ROS). The present study indicates that MPP+-
induced ROS formation is not mitochondrial in origin but results from intracellular dopamine
(DA) oxidation. Although a mean lethal dose of MPP+ led to ROS production in identified
dopaminergic neurons, toxic doses of the Complex I inhibitor rotenone did not. Concurrent …
dopaminergic terminals is thought to block Complex I activity leading to ATP loss and
overproduction of reactive oxygen species (ROS). The present study indicates that MPP+-
induced ROS formation is not mitochondrial in origin but results from intracellular dopamine
(DA) oxidation. Although a mean lethal dose of MPP+ led to ROS production in identified
dopaminergic neurons, toxic doses of the Complex I inhibitor rotenone did not. Concurrent …