[HTML][HTML] A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient …
ML Brennan, W Wu, X Fu, Z Shen, W Song… - Journal of Biological …, 2002 - ASBMB
Nitrotyrosine is widely used as a marker of post-translational modification by the nitric oxide
(⋅ NO, nitrogen monoxide)-derived oxidant peroxynitrite (ONOO−). However, since the
discovery that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) can generate
nitrotyrosine via oxidation of nitrite (NO 2−), several questions have arisen. First, the relative
contribution of peroxidases to nitrotyrosine formation in vivo is unknown. Further, although
evidence suggests that the one-electron oxidation product, nitrogen dioxide (⋅ NO 2), is the …
(⋅ NO, nitrogen monoxide)-derived oxidant peroxynitrite (ONOO−). However, since the
discovery that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) can generate
nitrotyrosine via oxidation of nitrite (NO 2−), several questions have arisen. First, the relative
contribution of peroxidases to nitrotyrosine formation in vivo is unknown. Further, although
evidence suggests that the one-electron oxidation product, nitrogen dioxide (⋅ NO 2), is the …