Blood superoxide dismutase, catalase and glutathione peroxidase activities in familial and sporadic amyotrophic lateral sclerosis
S Przedborski, DM Donaldson, PL Murphy, O Hirsch… - …, 1996 - Elsevier
Recent studies have implicated free radicals in the pathogenesis of amyotrophic lateral
sclerosis (ALS), a fatal, paralytic disorder of motor neurons. Herein we report on
measurements of erythrocyte activity of the three main free radical scavenging enzymes:
copper/zinc superoxide dismutase (Cu/Zn-SOD), catalase, and glutathione peroxidase. We
studied 31 patients with sporadic ALS, 18 with familial ALS, and 24 controls, Mean Cu/Zn-
SOD activity was reduced in eight familial ALS patients with mutations of Cu/Zn-SOD but …
sclerosis (ALS), a fatal, paralytic disorder of motor neurons. Herein we report on
measurements of erythrocyte activity of the three main free radical scavenging enzymes:
copper/zinc superoxide dismutase (Cu/Zn-SOD), catalase, and glutathione peroxidase. We
studied 31 patients with sporadic ALS, 18 with familial ALS, and 24 controls, Mean Cu/Zn-
SOD activity was reduced in eight familial ALS patients with mutations of Cu/Zn-SOD but …