[HTML][HTML] ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages: mechanism involves enhanced ABCA1 degradation in a process …
B Feng, I Tabas - Journal of Biological Chemistry, 2002 - ASBMB
In advanced atherosclerosis, macrophage foam cells progressively accumulate large
amounts of unesterified or" free" cholesterol (FC), a process that is thought to contribute to
foam cell death and lesional necrosis. The cellular consequences of early FC accumulation,
including those that lead to further FC accumulation, are poorly understood. In this context,
we show that cholesterol and phospholipid efflux mediated by ABCA1, which is initially
induced in the cholesterol-loaded macrophage, was inhibited by∼ 80% in pre-toxic FC …
amounts of unesterified or" free" cholesterol (FC), a process that is thought to contribute to
foam cell death and lesional necrosis. The cellular consequences of early FC accumulation,
including those that lead to further FC accumulation, are poorly understood. In this context,
we show that cholesterol and phospholipid efflux mediated by ABCA1, which is initially
induced in the cholesterol-loaded macrophage, was inhibited by∼ 80% in pre-toxic FC …