Liver toxicity and apoptosis: role of TGF-β1, cytochrome c and the apoptosome
K Cain, C Freathy - Toxicology letters, 2001 - Elsevier
Transforming growth factor-β1 (TGF-β1), is involved in controlling liver size, by inducing
apoptotic cell death in hepatocytes. However the mechanism by which TGF-β1 induces
caspase activation and cell death is unknown. Apoptosis can be initiated either by receptor-
mediated (eg Fas/CD95) or non-receptor chemically mediated (stress-induced) processes.
With Fas/CD95 receptor mediated cell death, a multi-protein complex (DISC) is assembled
at the plasma membrane, which activates the downstream caspases and cell death. In stress …
apoptotic cell death in hepatocytes. However the mechanism by which TGF-β1 induces
caspase activation and cell death is unknown. Apoptosis can be initiated either by receptor-
mediated (eg Fas/CD95) or non-receptor chemically mediated (stress-induced) processes.
With Fas/CD95 receptor mediated cell death, a multi-protein complex (DISC) is assembled
at the plasma membrane, which activates the downstream caspases and cell death. In stress …