[HTML][HTML] Autocrine regulation of macrophage differentiation and 92-kDa gelatinase production by tumor necrosis factor-α via α5β1 integrin in HL-60 cells
B Xie, A Laouar, E Huberman - Journal of Biological Chemistry, 1998 - ASBMB
Tumor necrosis factor-α (TNF-α) gene is one of the early response genes induced by
phorbol 12-myristate 13-acetate (PMA) in human HL-60 myeloid leukemia cells. In the
present study, we examined the role of the TNF-α autocrine loop in PMA-induced
macrophage differentiation and gene expression of 92-and 72-kDa gelatinases (MMP-9 and
MMP-2). In HL-60 cells, PMA inhibited cell proliferation and induced cell adhesion and
spreading, expression of surface maturation marker OKM1 and phagocytic activity, as well …
phorbol 12-myristate 13-acetate (PMA) in human HL-60 myeloid leukemia cells. In the
present study, we examined the role of the TNF-α autocrine loop in PMA-induced
macrophage differentiation and gene expression of 92-and 72-kDa gelatinases (MMP-9 and
MMP-2). In HL-60 cells, PMA inhibited cell proliferation and induced cell adhesion and
spreading, expression of surface maturation marker OKM1 and phagocytic activity, as well …