[HTML][HTML] The high affinity heparin-binding domain and the V region of fibronectin mediate invasion of human oral squamous cell carcinoma cells in vitro
YL Kapila, J Niu, PW Johnson - Journal of Biological Chemistry, 1997 - ASBMB
Fibronectin is an extracellular matrix molecule composed of repeating subunits that create
functional domains. These domains contain multiple binding sites for heparin and for various
cell-surface receptors that modulate cell function. To examine the role that the high affinity
heparin-binding region and the alternatively spliced V region of fibronectin play in tumor
invasion, we expressed and purified four complementary recombinant fibronectin proteins.
These proteins either included or excluded the alternatively spliced V region and contained …
functional domains. These domains contain multiple binding sites for heparin and for various
cell-surface receptors that modulate cell function. To examine the role that the high affinity
heparin-binding region and the alternatively spliced V region of fibronectin play in tumor
invasion, we expressed and purified four complementary recombinant fibronectin proteins.
These proteins either included or excluded the alternatively spliced V region and contained …