Normal liver regeneration in p50/nuclear factor κB1 knockout mice
RA DeAngelis, K Kovalovich, DE Cressman, R Taub - Hepatology, 2001 - Elsevier
Nuclear factor κB (NF-κB) is rapidly activated during liver regeneration following partial
hepatectomy or carbon tetrachloride (CCl4)-mediated liver injury and is felt to be important
in the antiapoptotic and regenerative responses. After partial hepatectomy, livers of mice
deficient in the p50 subunit of NF-κB (p50−/−) showed a loss of NF-κB and decreased
STAT3 transcription factor DNA binding activities. However, nuclear levels of the NF-κB p65
subunit were increased and peaked earlier in p50−/− livers. Both messenger RNA and …
hepatectomy or carbon tetrachloride (CCl4)-mediated liver injury and is felt to be important
in the antiapoptotic and regenerative responses. After partial hepatectomy, livers of mice
deficient in the p50 subunit of NF-κB (p50−/−) showed a loss of NF-κB and decreased
STAT3 transcription factor DNA binding activities. However, nuclear levels of the NF-κB p65
subunit were increased and peaked earlier in p50−/− livers. Both messenger RNA and …