Mice lacking α-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development

JT Lu, YJ Son, J Lee, TL Jetton, M Shiota… - Molecular and Cellular …, 1999 - Elsevier
α-Calcitonin gene-related peptide (αCGRP) is a pleiotropic peptide neuromodulator that is
widely expressed throughout the central and peripheral nervous systems. CGRP has been
implicated in a variety of physiological processes including peripheral vasodilation, cardiac
acceleration, nicotinic acetylcholine receptor (AChR) synthesis and function, testicular
descent, nociception, carbohydrate metabolism, gastrointestinal motility, neurogenic
inflammation, and gastric acid secretion. To provide a better understanding of the …