[HTML][HTML] Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling
BG Gálvez, S Matı́as-Román, JP Albar… - Journal of biological …, 2001 - ASBMB
Matrix metalloproteinases are thought to play an important role in endothelial cell migration
and matrix remodeling. We have used an in vitro wound healing migration model and newly
generated anti-membrane type 1-matrix metalloproteinase (MT1-MMP) monoclonal
antibodies (mAbs) to characterize the role of MT1-MMP during this process. First, the
expression and shedding of MT1-MMP are up-regulated upon induction of migration in
endothelial cells, as demonstrated by flow cytometry and Western blot analysis …
and matrix remodeling. We have used an in vitro wound healing migration model and newly
generated anti-membrane type 1-matrix metalloproteinase (MT1-MMP) monoclonal
antibodies (mAbs) to characterize the role of MT1-MMP during this process. First, the
expression and shedding of MT1-MMP are up-regulated upon induction of migration in
endothelial cells, as demonstrated by flow cytometry and Western blot analysis …